Naval Dockyards and the Mesothelioma Threat

When asbestos is disturbed or damaged, the small fibers can break away and float like dust in the air. If these fibers are inhaled, they can settle in the lungs, and over several years to bring to life threatening health problems. ; An interesting study entitled "Radiological examination of men exposed to asbestos in naval dockyards," according to Harries PG, Mackenzie FAF, G. sheers, JH Kemp, TP Oliver, DS Wright - Br J Ind Med 1972, 29:274-279. Here is an excerpt:. "Summary - Radiological examination of men exposed to asbestos in naval dockyards asbestos-related abnormalities were found in 3% of 10% of the sample population in radiological studies marine dockyards at Portsmouth, Chatham and Rosyth. Incidence of these abnormalities was related to the type of occupation and duration of exposure asbestos. results confirm findings from earlier research on the Devonport shipyard. There is no connection between smoking and amount smoked and the incidence of parenchymal or pleural disease due to exposure to asbestos was discovered. pleural abnormalities were found 10 times more frequent than parenchymal disease, a concern is felt over the uncertainty of forecasts in men with pleural abnormalities, especially because 37 people have developed pleural mesothelioma in Devonport since 1965. more work is needed to determine the true meaning of pleural abnormalities caused by asbestos and explore possible methods of treatment. "

Another study called "parietal pleural plaques, asbestos bodies, and neoplasia of the clinical, pathological, and roentgenographic correlation of 25 consecutive cases bear SL, Rogge VL, Foster WL Jr. - Chest 1984 Studen; .. 86 (5). :707-13 Here's an excerpt: "Abstract - The investigation has been made to link the autopsy findings and roentgenographic pleural plaques with occupational exposure to asbestos and the occurrence of respiratory tract tumors. Of 434 autopsies performed over 2 1 / 2 years, 25 (5.8 percent) had pleural plaques, but no gross evidence of parenchymal fibrosis. View the back-front chest roentgenograms using International Labour Office criteria for the classification of pneumoconiosis (1980) found that only seven of 25 cases were recognized pleural thickening or calcification, which indicates poor sensitivity of standard x-ray films. There was no difference in the frequency detect known or presumed exposure to asbestos pleural plate between cases and controls as determined by the occupational information obtained from chart review. Asbestos bodies were identified in lung tissue digests from all 25 cases of pleural plaques, and more normal range for our laboratory in 14 cases (56 percent). Of the 25 cases of pleural plaques, four also had bronchogenic and three laryngeal karcinom.Prevalencija bronchogenic carcinoma in patients with panels was not different from those without plaques (p greater than 0.50). However, the relationship between plaques and laryngeal cancer was highly significant (p = 0.004). "

If you find some of these studies is interesting, please read them in full. We all owe much gratitude to people who study these important issues.

Sensitivity and specificity of the linkage procedure with occupational activity in asbestos production

Another interesting study titled "Rat Lung Response to Inhaled chrysotile asbestos following acute and Subchronic Exposure" - 1983, Vol. 5, issue 1, pages 1-21
Experimental Lung Research - Here's an excerpt: "Inhalation of asbestos fibers can cause fibrotic and malignant diseases of the lungs early in vivo interactions between particles and the lung tissue that are at the beginning of the disease have received little study of male and female Fischer 344 rats were located in the .. inhalation chambers and exposed to 9.06 ± 1.83 mg/m3 (average inhaled mass) of chrysotile asbestos for 1 hour, 1 day, 7 hrlday for 5 days or 5 days / week for 3 months.

Qualitative examination of tissue showed that, after 1 days, the fibers were found not only in alveolar macrophages, and epithelium and interstitium of the alveolar region. after 3 months, numerous fibers were present in the epithelium and interstitium. morphometric analysis of tissue showed that these sections are also the most significant change as a result of exposure to asbestos. the majority of epithelial changes attributable to the 57% increase in type II cells and 90% increase in average cell volume. interstitial cell population increased 58% to 40% increase in average cell volume. there was no significant increase in the volume of noncellular interstitium. morphology and interstitial cells are showed that interstitial macrophages are, almost the entire increase in this population and that 88% of fibers contain macrophage cells. a few interstitial macrophages are associated membrane inclusions that showed x-ray energy spectrometry is microcalcifications. they were composed of calcium phosphate granules rings around asbestos fibers. microcalcifications This May indicate sublethal cell injury uzrokovaneprisutnosti asbestos fibers in the cell cytoplasm ."

We all owe a debt of gratitude to these fine scholars important work. If you find any of these statements of support, read the study in its entirety.