Sensitivity and specificity of the linkage procedure with occupational activity in asbestos production

Another interesting study titled "Rat Lung Response to Inhaled chrysotile asbestos following acute and Subchronic Exposure" - 1983, Vol. 5, issue 1, pages 1-21
Experimental Lung Research - Here's an excerpt: "Inhalation of asbestos fibers can cause fibrotic and malignant diseases of the lungs early in vivo interactions between particles and the lung tissue that are at the beginning of the disease have received little study of male and female Fischer 344 rats were located in the .. inhalation chambers and exposed to 9.06 ± 1.83 mg/m3 (average inhaled mass) of chrysotile asbestos for 1 hour, 1 day, 7 hrlday for 5 days or 5 days / week for 3 months.

Qualitative examination of tissue showed that, after 1 days, the fibers were found not only in alveolar macrophages, and epithelium and interstitium of the alveolar region. after 3 months, numerous fibers were present in the epithelium and interstitium. morphometric analysis of tissue showed that these sections are also the most significant change as a result of exposure to asbestos. the majority of epithelial changes attributable to the 57% increase in type II cells and 90% increase in average cell volume. interstitial cell population increased 58% to 40% increase in average cell volume. there was no significant increase in the volume of noncellular interstitium. morphology and interstitial cells are showed that interstitial macrophages are, almost the entire increase in this population and that 88% of fibers contain macrophage cells. a few interstitial macrophages are associated membrane inclusions that showed x-ray energy spectrometry is microcalcifications. they were composed of calcium phosphate granules rings around asbestos fibers. microcalcifications This May indicate sublethal cell injury uzrokovaneprisutnosti asbestos fibers in the cell cytoplasm ."

We all owe a debt of gratitude to these fine scholars important work. If you find any of these statements of support, read the study in its entirety.